Wrinkles in human facial skin are mostly caused by collagen relaxation and involuntary contraction of muscles. If the contraction of these muscles can be controlled, the skin muscles can be relaxed to relieve wrinkles and achieve the fundamental purpose of removing wrinkles. Botulinum toxin, as an effective wrinkle removal method, is widely known for its excellent effect. Even if it will cause great risks after use, there will still be a large number of consumers willing to use it. Polypeptide is different. As an organic synthetic product, when used as a cosmetic ingredient, it can be rapidly degraded into free amino acids at low concentration. Its main sequence is based on human body and its mechanism of action is natural. The characteristics of small molecular peptides enable them to have good transdermal permeability and are well absorbed by the human body. Acetyl hexapeptide -8 prevents nerve from transmitting muscle contraction information through the mechanism similar to botulinum toxin, so that muscle cannot contract to eliminate wrinkles. It has high anti-wrinkle activity and few side effects, and has been widely used in various high-end cosmetics.